In 2001 Sisse Marie won the most prestigious song contest for young people on Danish national television, which led to a gold certified album. The following year she received the Grammy for Best Teen Album. After that she began a very successful international modelling career working in Milan, London, Munich, Atlanta, Amsterdam, Istanbul, Copenhagen and Stockholm to name but a few.

She has done model photos, catalogues and billboards for international brands like Volvo, Heineken, Citroën, Wonderbra, Pilgrim and O'Neill and photo series and covers off leading magazines like Cosmopolitan, T3, Ché, Marie Claire and has, among other things, walked the runway for Italian Vogue.

While working as a model Sisse Marie also released a top 5 single and hosted the most watched show on Danish MTV for two seasons.

In November 2010 she released the gold certified single "Every Time (You Look At Me)". The song went straight to number 1 in Denmark and the music video was on the release day the 8th most watched on YouTube in the world! After that she closed major endorsement deals with Smirnoff, Pilgrim and Citroen.

Her next single, a club orientated house anthem, "Dirty Hands" went number 1 on MTV, performed on charts for several weeks on MTV Brazil, and was a big club hit. This February she released the new single "Kill For Your Love". It immediately went number 1 on MTV and national television.

Sisse Marie has recently been on two extensive tours in China where she played in the biggest clubs all over the huge country. She has been playing more than a 100 shows and festivals in Denmark and USA including the Playboy Mansion and Nokia Theater in New York Times Square as the main event.